In this paper, an analytical study was carried out to propose an optimum base-isolated system for the design of steel structures equipped with lead rubber bearings (LRB). For this, 5 and 10-storey steel moment resisting frames (MRFs) were designed as Special Moment Frame (SMF). These two-dimensional and three-bay frames equipped with a set of isolation systems within a predefined range that minimizes the response of the base-isolated frames subjected to a series of earthquakes. In the design of LRB, two main parameters, namely, isolation period (T) and the ratio of strength to weight (Q/W) supported by isolators were considered as 2.25, 2.5, 2.75 and 3 s, 0.05, 0.10 and 0.15, respectively. The Force-deformation behavior of the isolators was modelled by the bi-linear behavior which could reflect the nonlinear characteristics of the lead-plug bearings. The base-isolated frames were modelled using a finite element program and those performances were evaluated in the light of the nonlinear time history analyses by six natural accelerograms compatible with seismic hazard levels of 2% probability of exceedance in 50 years. The performance of the isolated frames was assessed in terms of roof displacement, relative displacement, interstorey drift, absolute acceleration, base shear and hysteretic curve.