Basilicas constructed in the post-Byzantine time in Balkans cover a period of 400 years, from the 16th century to the 19th century. These masonry religious objects are of particular interest due to their different building typologies and historical value, so it is important that they be saved for future generations. This paper analyses the static and dynamic response of the Basilica of St. Sotiri near Gjirokaster (Albania). The static response and dynamic properties of the church have been assessed using FEM technique and the performance of the structure is investigated. As a result, important information is obtained to identify the critical regions of the structure and its seismic safety. The aim of this study is to point out that clear insight and information on interpreting the actual response of historical buildings can be obtained by numerical analysis methods. Authors believe that the approach and findings of this case study are useful to understand the load response of a wide range of monumental churches.